Afua Dufie died instantly on Tuesday at about 5 p.m. when the suspected mental patient inflicted multiple injuries on her at Mpasaso-Adiembra, also in the Ahafo Ano South District.
Police say the deranged woman had earlier attempted to attack her own mother before turning to Dufie and her husband.
Afua Dufie was escorting her sick husband to the hospital when the calamity befell her.
District Police Commander, DSP Augustine Mensah told Nhyira News that the incident left the deceased with a severely disfigured, her head hacked several times with the axe.
Meanwhile, police have arrested and detained the woman pending further investigations.
The body of Afua Dufie has been deposited at the Toase Government Hospital awaiting autopsy.